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The emergence of a novel coronavirus (SARS-CoV-2), their biology and therapeutic options.

Identifieur interne : 000148 ( an2020/Analysis ); précédent : 000147; suivant : 000149

The emergence of a novel coronavirus (SARS-CoV-2), their biology and therapeutic options.

Auteurs : Suliman Khan [République populaire de Chine] ; Rabeea Siddique [République populaire de Chine] ; Muhammad Adnan Shereen [République populaire de Chine] ; Ashaq Ali [République populaire de Chine] ; Jianbo Liu ; Qian Bai [République populaire de Chine] ; Nadia Bashir [République populaire de Chine] ; Mengzhou Xue [République populaire de Chine]

Source :

RBID : pubmed:32161092

Abstract

The new decade of the 21st century (2020) started with the emergence of novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in humans. The source of origin, transmission to humans and mechanisms associated with the pathogenicity of SARS-CoV-2 are not clear yet, however, its resemblance with SARS-CoV and several other bat coronaviruses was recently confirmed through genome sequencing related studies. The development of therapeutic strategies is necessary in order to prevent further epidemics and cure infected people. In this Review, we summarize current information about the emergence, origin, diversity, and epidemiology of three pathogenic coronaviruses with a specific focus on the current outbreak in Wuhan, China. Furthermore, we discuss the clinical features and potential therapeutic options that may be effective against SARS-CoV-2.

DOI: 10.1128/JCM.00187-20
PubMed: 32161092


Affiliations:


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<div type="abstract" xml:lang="en">The new decade of the 21
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century (2020) started with the emergence of novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in humans. The source of origin, transmission to humans and mechanisms associated with the pathogenicity of SARS-CoV-2 are not clear yet, however, its resemblance with SARS-CoV and several other bat coronaviruses was recently confirmed through genome sequencing related studies. The development of therapeutic strategies is necessary in order to prevent further epidemics and cure infected people. In this Review, we summarize current information about the emergence, origin, diversity, and epidemiology of three pathogenic coronaviruses with a specific focus on the current outbreak in Wuhan, China. Furthermore, we discuss the clinical features and potential therapeutic options that may be effective against SARS-CoV-2.</div>
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